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Case Reports
. 2020 Aug 3;33(4):653-654.
doi: 10.1080/08998280.2020.1798724.

Naproxen-induced thrombocytopenia

Nitasa Sahu  1 , Justin Roy  1 , Rama Vunnam  1 , Reshma Golamari  1 , Rohit Jain  1
Affiliations
Case Reports

Naproxen-induced thrombocytopenia

Nitasa Sahu et al. Proc (Bayl Univ Med Cent). .

Abstract

Thrombocytopenia has many mechanisms with broad differentials. A detailed history and physical, with timely diagnostic testing, is necessary to parse out the underlying etiology. Clinicians should maintain a high suspicion for drug-induced thrombocytopenia when there is an acute drop in the platelet level after exposure to commonly implicated drugs. Drug-induced thrombocytopenia is not well defined, as reporting is voluntary and not critically reviewed. Oftentimes, the culprit is not the drug itself, but a drug metabolite, which is difficult to prove with drug-dependent antibody testing. Here we present a case where naproxen led to hemarthrosis secondary to drug-induced thrombocytopenia.

Keywords: Drug-induced thrombocytopenia; hematology; internal medicine.

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Figure 1.
Figure 1.
Platelet count trend from admission to discharge. The star indicates when dexamethasone was initiated.
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